The book Medical Ventilation Systems: Principles, Technologies, and Clinical Applications offers a comprehensive overview of the science and practice of mechanical ventilation in modern healthcare. It explains the fundamental principles of ventilation, covering respiratory physiology, gas exchange, and patient-ventilator interaction. The book highlights advancements in ventilator technologies, modes of ventilation, and monitoring systems that enhance patient safety and outcomes. It explores clinical applications across critical care, anesthesia, emergency medicine, and long-term respiratory support. Practical insights into ventilator management for diverse patient populations, including neonates, adults, and those with chronic respiratory diseases, are provided. Emphasis is placed on evidence-based approaches, troubleshooting, and the integration of intelligent and automated systems in clinical settings. The book also discusses challenges such as ventilator-associated complications and strategies for improving efficiency and patient comfort. Designed as a valuable reference, it is ideal for clinicians, biomedical engineers, researchers, and students in the fields of medicine and healthcare technology. By blending theory with real-world practice, this volume bridges the gap between engineering innovation and clinical application in respiratory care.